Article
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.
Nature reviews. Rheumatology - 1 Dec 2016
Brown Philip M, Pratt Arthur G, Isaacs John D
Abstract excerpt
The treatment and outcomes of patients with rheumatoid arthritis (RA) have been transformed over the past two decades. Low disease activity and remission are now frequently achieved, and this success is largely the result of the evolution of treatment paradigms and the introduction of new therapeutic agents. Despite the rapid pace of change, the most commonly used drug in RA remains methotrexate, which is...
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