Article
Utilization of amplicon-based targeted sequencing panel for the massively parallel sequencing of sporadic hearing impairment patients from Saudi Arabia.
BMC medical genetics - 10 Oct 2016
Dallol Ashraf, Daghistani Kamal, Elaimi Aisha, Al-Wazani Wissam A, Bamanie Afaf, Safiah Malek, Sagaty Samira, Taha Layla, Zahed Rawabi, Bajouh Osama, Chaudhary Adeel Gulzar, Gari Mamdooh Abdullah, Turki Rola, Al-Qahtani Mohammed Hussein, Abuzenadah Adel Mohammed
Abstract excerpt
BACKGROUND: Hearing Impairment (HI) can have genetic or environmental causes and in some cases, an interplay of both. Genetic causes are difficult to determine as mutations in more than 90 genes have been shown recently to be responsible for HI. Providing a genetic diagnostic test for HI is therefore a challenge especially for ethnic groups where GJB2 mutations are shown to be rare. RESULTS: Here we show the...
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