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Article

Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.

Scientific reports - 21 Oct 2016

Dong Peixin, Xiong Ying, Watari Hidemichi, Hanley Sharon Jb, Konno Yosuke, Ihira Kei, Suzuki Fumihiko, Yamada Takahiro, Kudo Masataka, Yue Junming, Sakuragi Noriaki

Abstract excerpt

Derepression of wild-type p53 by suppressing its negative inhibitor iASPP (Inhibitor of apoptosis-stimulating protein of p53) represents a potential therapeutic option for cervical cancer (CC). Here, we reported a novel functional significance of iASPP upregulation in cervical tumorigenesis: iASPP acts as a key promoter of CC cell proliferation, epithelial-mesenchymal transition, invasion and cancer stemness, by...

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Identifiers

PMID: 27765948
DOI: 10.1038/srep35480
PMCID: PMC5073231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.PMID 27765948Read ↗

Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumorsSemantic proximity Read ↗

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