Article
Production of a Locus- and Allele-Specific Monoclonal Antibody for the Characterization of SLA-1*0401 mRNA and Protein Expression Levels in MHC-Defined Microminipigs.
PloS one - 1 Jan 2016
Kametani Yoshie, Ohshima Shino, Miyamoto Asuka, Shigenari Atsuko, Takasu Masaki, Imaeda Noriaki, Matsubara Tatsuya, Tanaka Masafumi, Shiina Takashi, Kamiguchi Hiroshi, Suzuki Ryuji, Kitagawa Hitoshi, Kulski Jerzy K, Hirayama Noriaki, Inoko Hidetoshi, Ando Asako
Abstract excerpt
The class I major histocompatibility complex (MHC) presents self-developed peptides to specific T cells to induce cytotoxity against infection. The MHC proteins are encoded by multiple loci that express numerous alleles to preserve the variability of the antigen-presenting ability in each species. The mechanism regulating MHC mRNA and protein expression at each locus is difficult to analyze because of the...
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