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Article

A Marfan syndrome-like phenotype caused by a neocentromeric supernumerary ring chromosome 15.

American journal of medical genetics. Part A - 1 Jan 2017

Quinonez Shane C, Gelehrter Thomas D, Uhlmann Wendy R

Abstract excerpt

Small supernumerary marker chromosomes (sSMC) are abnormal chromosomes that cannot be characterized by standard banding cytogenetic techniques. A minority of sSMC contain a neocentromere, which is an ectopic centromere lacking the characteristic alpha-satellite DNA. The phenotypic manifestations of sSMC and neocentromeric sSMC are variable and range from severe intellectual disability and multiple congenital...

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Share to Centromere
Share to Chromosome Banding
Share to Chromosomes, Human, Pair 15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 27739187
DOI: 10.1002/ajmg.a.38000

Genes

FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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