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Article

ACAN Gene Mutations in Short Children Born SGA and Response to Growth Hormone Treatment.

The Journal of clinical endocrinology and metabolism - 1 May 2017

van der Steen Manouk, Pfundt Rolph, Maas Stephan J W H, Bakker-van Waarde Willie M, Odink Roelof J, Hokken-Koelega Anita C S

Abstract excerpt

Background: Some children born small for gestational age (SGA) show advanced bone age (BA) maturation during growth hormone (GH) treatment. ACAN gene mutations have been described in children with short stature and advanced BA. Objective: To determine the presence of ACAN gene mutations in short SGA children with advanced BA and assess the response to GH treatment. Methods: BA assessment in 290 GH-treated SGA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27710243
DOI: 10.1210/jc.2016-2941

Genes

ACAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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