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Article

LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse

30 Sept 2016

Abstract excerpt

Premature ovarian failure and female infertility are frequent side effects of anticancer therapies, owing to the extreme sensitivity of the ovarian reserve oocytes to the damaging effects of irradiation and chemotherapy on DNA. We report here a robust protective effect of luteinizing hormone (LH) on the primordial follicle pool of prepubertal ovaries against the cisplatin (Cs)-induced apoptosis. In vitro LH...

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Identifiers

PMID: 27689876
DOI: 10.1038/cdd.2016.97

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