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Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system

26 Sept 2016

Abstract excerpt

BACKGROUND: β-thalassemia comprises a major group of human genetic disorders involving a decrease in or an end to the normal synthesis of the β-globin chains of hemoglobin. KLF1 is a key regulatory molecule involved in the γ- to β-globin gene switching process directly inducing the expression of the β-globin gene and indirectly repressing γ-globin. The present study aimed to investigate the ability of an...

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PMID: 27668420
DOI: 10.1002/jgm.2928

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