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Article

Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages.

Virology - 1 Dec 2016

Agosto Luis M, Hirnet Juliane B, Michaels Daniel H, Shaik-Dasthagirisaheb Yazdani B, Gibson Frank C, Viglianti Gregory, Henderson Andrew J

Abstract excerpt

Periodontal infections contribute to HIV-associated co-morbidities in the oral cavity and provide a model to interrogate the dysregulation of macrophage function, inflammatory disease progression, and HIV replication during co-infections. We investigated the effect of Porphyromonas gingivalis on the establishment of HIV infection in monocyte-derived macrophages. HIV replication in macrophages was significantly...

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Share to Antigens, Surface
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

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Share to Leukocytes, Mononuclear

Share to Microbial Interactions

Share to Porphyromonas gingivalis

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 27639573
DOI: 10.1016/j.virol.2016.09.007
PMCID: PMC5126732

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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