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Article

GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.

PloS one - 1 Jan 2016

Young Alejandra, Dandekar Uma, Pan Calvin, Sader Avery, Zheng Jie J, Lewis Richard A, Farber Debora B

Abstract excerpt

Ocular albinism type 1 (OA), caused by mutations in the OA1 gene, encodes a G-protein coupled receptor, OA1, localized in melanosomal membranes of the retinal pigment epithelium (RPE). This disorder is characterized by both RPE macro-melanosomes and abnormal decussation of ganglion cell axons at the brain's optic chiasm. We demonstrated previously that Oa1 specifically activates Gαi3, which also signals in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27607449
DOI: 10.1371/journal.pone.0162273
PMCID: PMC5015898

Genes

GNAI3
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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