Impact of circulating resistance-associated mutations on HIV pre-exposure prophylaxis (PrEP) efficacy: Modeling from antiretroviral resistance cohort analysis (ARCA) national database.

Abstract excerpt

BACKGROUND: PrEP with FTC/TDF has shown great efficacy in preventing new HIV infections but issues remain (low adherence, high costs, toxicity and resistance development). No data are available about the impact of circulating Resistance-Associated Mutations (RAMs) on its efficacy. OBJECTIVES: describe the prevalence of FTC and/or TDF-related RAMs in Italian HIV-infected population and their potential impact on...

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