Article
Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies.
Journal of translational medicine - 1 Sept 2016
Frazzi Raffaele, Auffray Charles, Ferrari Angela, Filippini Perla, Rutella Sergio, Cesario Alfredo
Abstract excerpt
Although survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome...
Topics
- Animals
- High-Throughput Nucleotide Sequencing
- Humans
- Lymphoma
- Molecular Targeted Therapy
- Mutation
- Prognosis
- Proteomics
