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Article

Sorafenib Therapy for Pediatric Acute Myeloid Leukemia with FMS-like Tyrosine Kinase 3-internal Tandem Duplication Mutations: 2 Case Reports.

Journal of pediatric hematology/oncology - 1 May 2017

Osone Shinya, Imamura Toshihiko, Kanayama Takuyo, Tsuma Yusuke, Kawashima-Goto Sachiko, Nakatani Takuya, Sugimoto Atsuya, Takai Akari, Miyachi Mitsuru, Tamura Shinichi, Ishida Hiroyuki, Hosoi Hajime

Abstract excerpt

Sorafenib is a promising agent for treating pediatric refractory acute myeloid leukemia (AML) exhibiting FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD); however, its optimal use needs to be established. We report 2 cases of refractory pediatric FLT3-ITD-positive AML treated with sorafenib. Case 1 underwent stem cell transplantation (SCT) without entering remission, despite the use of...

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Identifiers

PMID: 27571118
DOI: 10.1097/MPH.0000000000000672

Genes

SCT
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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