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Update on Leukodystrophies: A Historical Perspective and Adapted Definition

26 Aug 2016

Abstract excerpt

Leukodystrophies were defined in the 1980s as progressive genetic disorders primarily affecting myelin of the central nervous system. At that time, a limited number of such disorders and no associated gene defects were known. The majority of the leukodystrophy patients remained without a specific diagnosis. In the following two decades, magnetic resonance imaging pattern recognition revolutionized the field,...

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PMID: 27564080
DOI: 10.1055/s-0036-1588020

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