Article
p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading.
BMC cancer - 18 Aug 2016
Guerra Emanuela, Cimadamore Alessia, Simeone Pasquale, Vacca Giovanna, Lattanzio Rossano, Botti Gerardo, Gatta Valentina, D'Aurora Marco, Simionati Barbara, Piantelli Mauro, Alberti Saverio
Abstract excerpt
BACKGROUND: Traditional prognostic indicators of breast cancer, i.e. lymph node diffusion, tumor size, grading and estrogen receptor expression, are inadequate predictors of metastatic relapse. Thus, additional prognostic parameters appear urgently needed. Individual oncogenic determinants have largely failed in this endeavour. Only a few individual tumor growth drivers, e.g. mutated p53, Her-2, E-cadherin,...
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