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Article

Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype.

Autism research : official journal of the International Society for Autism Research - 1 Mar 2017

Rijlaarsdam Jolien, van IJzendoorn Marinus H, Verhulst Frank C, Jaddoe Vincent W V, Felix Janine F, Tiemeier Henning, Bakermans-Kranenburg Marian J

Abstract excerpt

Findings of studies investigating OXTR SNP rs53576 (G-A) variation in social behavior have been inconsistent, possibly because DNA methylation after stress exposure was eliminated from consideration. Our goal was to examine OXTR rs53576 allele-specific sensitivity for neonatal OXTR DNA methylation in relation to (1) a prenatal maternal stress composite, and (2) child autistic traits. Prospective data from fetal...

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Identifiers

PMID: 27520745
DOI: 10.1002/aur.1681
PMCID: PMC5426537

Genes

OXTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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