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Article

Anti‐tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells

8 Aug 2016

Abstract excerpt

Ataxia telangiectasia and Rad3‐related (ATR) proteins are sensors of DNA damage, which induces homologous recombination (HR)‐dependent repair. ATR is a master regulator of DNA damage repair (DDR), signaling to control DNA replication, DNA repair and apoptosis. Therefore, the ATR pathway might be an attractive target for developing new drugs. This study was designed to investigate the antitumor effects of the ATR...

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PMID: 27501113
DOI: 10.1002/ijc.30373

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