Article
The Ratio of Regulatory (FOXP3+) to Total (CD3+) T Cells Determined by Epigenetic Cell Counting and Cardiovascular Disease Risk: A Prospective Case-cohort Study in Non-diabetics.
EBioMedicine - 1 Sept 2016
Barth Sebastian Dietmar, Kaaks Rudolf, Johnson Theron, Katzke Verena, Gellhaus Katharina, Schulze Janika Josephin, Olek Sven, Kühn Tilman
Abstract excerpt
BACKGROUND: Experimental and clinical evidence indicate that inflammatory processes in atherogenesis and the development of cardiovascular complications are promoted by a loss of regulatory T cell (Treg)-mediated immunological tolerance to plaque antigens. Yet, the association between alterations of systemic Treg frequency and cardiovascular disease incidence remains uncertain. METHODS: A nested case-cohort study...
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