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Article

Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds.

Journal of translational medicine - 5 Aug 2016

Li Meng, Shu Xiangbing, Xu Hanchen, Zhang Chunlei, Yang Lili, Zhang Li, Ji Guang

Abstract excerpt

BACKGROUND: Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed a new therapeutic agent berberine compounds (BC), consisting of berberine, oryzanol and vitamin B6, and determined their anti-hyperlipidemia activity and underlying mechanisms. METHODS: Male Wistar rats were fed a high fat diet (HFD) to induce hyperlipidemia, and then given BC orally for...

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Identifiers

PMID: 27495782
DOI: 10.1186/s12967-016-0987-5
PMCID: PMC4975912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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