Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer.

doi:10.1158/1078-0432.CCR-16-1543

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Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2017

Parsons Heather A, Beaver Julia A, Cimino-Mathews Ashley, Ali Siraj M, Axilbund Jennifer, Chu David, Connolly Roisin M, Cochran Rory L, Croessmann Sarah, Clark Travis A, Gocke Christopher D, Jeter Stacie C, Kennedy Mark R, Lauring Josh, Lee Justin, Lipson Doron, Miller Vincent A, Otto Geoff A, Rosner Gary L, Ross Jeffrey S, Slater Shannon, Stephens Philip J, VanDenBerg Dustin A, Wolff Antonio C, Young Lauren E, Zabransky Daniel J, Zhang Zhe, Zorzi Jane, Stearns Vered, Park Ben H

Abstract excerpt

PURPOSE: The clinical utility of next-generation sequencing (NGS) in breast cancer has not been demonstrated. We hypothesized that we could perform NGS of a new biopsy from patients with metastatic triple-negative breast cancer (TNBC) in a clinically actionable timeframe. EXPERIMENTAL DESIGN: We planned to enroll 40 patients onto a prospective study, Individualized Molecular Analyses Guide Efforts (IMAGE), to...

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Identifiers

PMID: 27489289
DOI: 10.1158/1078-0432.CCR-16-1543
PMCID: PMC5241251

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