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Article

Loss of Hes1 expression is associated with poor prognosis in colorectal adenocarcinoma.

Human pathology - 1 Nov 2016

Ahadi Mahsa, Andrici Juliana, Sioson Loretta, Sheen Amy, Clarkson Adele, Gill Anthony J

Abstract excerpt

Alterations in the Notch signaling pathway play a role in colorectal cancer (CRC). Hes1, a Notch-induced transcription factor, has recently been reported to show decreased expression by immunohistochemistry in sessile serrated adenomas. Variable staining patterns have been reported in tubular adenomas, and existing data on Hes1 expression in CRC are limited and inconsistent. We therefore sought to investigate the...

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Source

Identifiers

PMID: 27476040
DOI: 10.1016/j.humpath.2016.07.010

Genes

HES1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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