Article
miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas.
Neuro-oncology - 1 Jan 2017
Li Shouwei, Zeng Ailiang, Hu Qi, Yan Wei, Liu Yanwei, You Yongping
Abstract excerpt
BACKGROUND: Gliomas are based on a genetic abnormality and present with a dismal prognosis. MicroRNAs (miRNAs) are considered to be important mediators of gene expression in glioma tissues. METHODS: Real-time PCR was used to analyze the expression of microRNA-423-5p (miR-423-5p) in human glioma samples and normal brain tissue. Apoptosis, cell cycle, proliferation, immunostaining, transwell, in vitro 2D and 3D...
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