Article
Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.
Journal of biomolecular screening - 1 Oct 2016
Severyn Bryan, Nguyen Thi, Altman Michael D, Li Lixia, Nagashima Kumiko, Naumov George N, Sathyanarayanan Sriram, Cook Erica, Morris Erick, Ferrer Marc, Arthur Bill, Benita Yair, Watters Jim, Loboda Andrey, Hermes Jeff, Gilliland D Gary, Cleary Michelle A, Carroll Pamela M, Strack Peter, Tudor Matt, Andersen Jannik N
Abstract excerpt
The RAS-MAPK pathway controls many cellular programs, including cell proliferation, differentiation, and apoptosis. In colorectal cancers, recurrent mutations in this pathway often lead to increased cell signaling that may contribute to the development of neoplasms, thereby making this pathway attractive for therapeutic intervention. To this end, we developed a 26-member gene signature of RAS-MAPK pathway...
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