Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii.

PloS one - 1 Jan 2016

Rommereim Leah M, Bellini Valeria, Fox Barbara A, Pètre Graciane, Rak Camille, Touquet Bastien, Aldebert Delphine, Dubremetz Jean-François, Cesbron-Delauw Marie-France, Mercier Corinne, Bzik David J

Abstract excerpt

Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of most of these proteins still remains unknown. We targeted gene knockouts at ten GRA gene loci (GRA1-10) to investigate the cellular roles and essentiality of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockout Techniques
Share to Gene Order

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Host-Parasite Interactions

Share to Protozoan Proteins

Share to Toxoplasma

Share to Toxoplasmosis

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 27458822
DOI: 10.1371/journal.pone.0159306
PMCID: PMC4961421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii.PMID 27458822Read ↗

Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection.Semantic proximity Read ↗

Intervacuolar Transport and Unique Topology of GRA14, a Novel Dense Granule Protein in Toxoplasma gondiiSemantic proximity Read ↗

GRA47 is important for the morphology and permeability of the parasitophorous vacuole in Toxoplasma gondiiSemantic proximity Read ↗

A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondiiSemantic proximity Read ↗

Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii InfectionSemantic proximity Read ↗

Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8+ T cells during the chronic stage of infectionSemantic proximity Read ↗

GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspeciesSemantic proximity Read ↗

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous VacuoleSemantic proximity Read ↗

Role of GRA41 in Neospora caninum pathogenicity: insights into tachyzoite egress and microneme secretionSemantic proximity Read ↗

Dense granule biogenesis, secretion, and function in Toxoplasma gondiiSemantic proximity Read ↗

Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.Semantic proximity Read ↗

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during <i>Toxoplasma gondii</i> infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.