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Article

Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2.

Oncotarget - 20 Sept 2016

Goldberg Alexander A, Joung Kwang-Bo, Mansuri Asma, Kang Yujin, Echavarria Raquel, Nikolajev Ljiljana, Sun Yang, Yu Jane J, Laporte Stephane A, Schwertani Adel, Kristof Arnold S

Abstract excerpt

Lymphangioleiomyomatosis (LAM) is a destructive lung disease that can arise sporadically or in adults suffering from the tumor syndrome tuberous sclerosis complex (TSC). Microscopic tumors ('LAM nodules') in the lung interstitium arise from lymphatic invasion and metastasis. These consist of smooth muscle-like cells (LAM cells) that exhibit markers of neural crest differentiation and loss of the tumor suppressor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27458154
DOI: 10.18632/oncotarget.10748
PMCID: PMC5308642

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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