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Article

Profiling gene mutations, translocations, and multidrug resistance in pediatric acute lymphoblastic leukemia: a step forward to personalizing medicine.

Medical oncology (Northwood, London, England) - 1 Sept 2016

Rose-James Alphy, Shiji R, Kusumakumary P, Nair Manjusha, George Suraj K, Sreelekha T T

Abstract excerpt

Precise risk stratification and tailored therapy in acute lymphoblastic leukemia (ALL) can lead to enhanced survival rates among children. Translocations and mutations along with multidrug resistance markers are important factors that determine therapeutic efficacy. Gene mutation profiling of patients at the time of diagnosis can offer accurate clinical decision-making. Multiplex PCR was used to screen for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27449773
DOI: 10.1007/s12032-016-0809-x

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FLT3

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