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Article

Hox6 genes modulate in vitro differentiation of mESCs to insulin-producing cells.

In vitro cellular & developmental biology. Animal - 1 Oct 2016

Larsen Brian M, Marty-Santos Leilani, Newman Micaleah, Lukacs Derek T, Spence Jason R, Wellik Deneen M

Abstract excerpt

The differentiation of glucose-responsive, insulin-producing cells from ESCs in vitro is promising as a cellular therapy for the treatment of diabetes, a devastating and common disease. Pancreatic β-cells are derived from the endoderm in vivo and therefore most current protocols attempt to generate a pure population of first endoderm, then pancreas epithelium, and finally insulin-producing cells. Despite this,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27444630
DOI: 10.1007/s11626-016-0066-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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