Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice.

doi:10.1016/j.neulet.2016.07.022

Article

Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice.

Neuroscience letters - 26 Aug 2016

Chen Jun, Kaitsuka Taku, Fujino Rika, Araki Kimi, Tomizawa Kazuhito, Yamamoto Tetsuro

Abstract excerpt

Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain...

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Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice.

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