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Article

Heterogeneity-mediated cellular adaptation and its trade-off: searching for the general principles of diseases.

Journal of evaluation in clinical practice - 1 Feb 2017

Heng Henry H

Abstract excerpt

Big-data-omics have promised the success of precision medicine. However, most common diseases belong to adaptive systems where the precision is all but difficult to achieve. In this commentary, I propose a heterogeneity-mediated cellular adaptive model to search for the general model of diseases, which also illustrates why in most non-infectious non-Mendelian diseases the involvement of cellular evolution is less...

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Identifiers

PMID: 27421676
DOI: 10.1111/jep.12598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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