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Article

[Evolutionary ontogenetic aspects of pathogenetics of chronic human diseases].

Genetika - 1 Dec 2011

Puzyrev V P, Kucher A N

Abstract excerpt

This article is a review of scientific publications, in which issues of pathogenetics of multifactorial diseases (MFDs) are considered from the viewpoint of evolution and ontogeny. Concepts explaining significance of evolutionary processes in the formation of genetic architecture of human chronic diseases ("thrifty" genomes and phenotypes, "drifting genes," decanalization) are analyzed. The roles of natural...

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PMID: 22384685

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