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Article

Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models

15 Jul 2016

Abstract excerpt

Cardiovascular complications are the leading cause of death in autosomal dominant polycystic kidney disease (ADPKD), and intracranial aneurysm (ICA) causing subarachnoid hemorrhage is among the most serious complications. The diagnostic and therapeutic strategies for ICAs in ADPKD have not been fully established. We here generated induced pluripotent stem cells (iPSCs) from seven ADPKD patients, including four...

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PMID: 27418197
DOI: 10.1038/srep30013

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