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Article

Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressiveness and Stem Cell-like Phenotype via Dysregulation of PITX2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2017

Zhang Jia-Xing, Chen Zhen-Hua, Xu Yi, Chen Jie-Wei, Weng Hui-Wen, Yun Miao, Zheng Zou-San, Chen Cui, Wu Bing-Li, Li En-Min, Fu Jian-Hua, Ye Sheng, Xie Dan

Abstract excerpt

PURPOSE: We previously reported the oncogenic role of paired-like homeodomain 2 (PITX2) in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to identify the miRNA regulators of PITX2 and the mechanism underlying the pathogenesis of ESCC. EXPERIMENTAL DESIGN: Using miRNA profiling and bioinformatics analyses, we identified miR-644a as a negative mediator of PITX2 in ESCC. A series of in vivo and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27407092
DOI: 10.1158/1078-0432.CCR-16-0414

Genes

PITX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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