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Article

Gut microbiome analysis in neuromyelitis optica reveals overabundance of <i>Clostridium perfringens</i>

12 Jul 2016

Abstract excerpt

T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin-4, exhibit Th17 polarization and cross-react with a homologous sequence of a Clostridium perfringens adenosine triphosphate-binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy...

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PMID: 27398819
DOI: 10.1002/ana.24718

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