Article
Efficacy of sofosbuvir plus ribavirin in treatment-naive patients with genotype-1 and -3 HCV infection: results from a Russian Phase IIIb study.
Antiviral therapy - 1 Jan 2016
Isakov Vasily, Zhdanov Konstantin, Kersey Kathryn, Svarovskaia Evguenia, Massetto Benedetta, Zhu Yanni, Knox Steven J, Bakulin Igor, Chulanov Vladimir
Abstract excerpt
BACKGROUND: In this Phase IIIb study, we evaluated the efficacy and safety of the oral nucleotide analogue inhibitor sofosbuvir plus ribavirin, with special attention given to viral resistance, in Russian patients with HCV genotype-1 or -3. METHODS: Treatment-naive patients with and without compensated cirrhosis were randomized (1:1) to receive 16 or 24 weeks of once-daily sofosbuvir 400 mg plus twice-daily oral...
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