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Article

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

29 Jun 2016

Abstract excerpt

Abstract Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs. Although some HDACi have entered the clinic, the mechanism(s) underlying their tumor selectivity are poorly understood. Experimental Design and Results: Using gene expression analysis, we define a core set of six genes commonly regulated in acute myeloid leukemia (AML) blasts and cell lines. MYC, the most prominently...

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PMID: 27358484
DOI: 10.1158/1078-0432.ccr-15-2388

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