Article
Loss of membranous VEGFR1 expression is associated with an adverse phenotype and shortened survival in breast cancer.
Molecular medicine reports - 1 Aug 2016
Lebok Patrick, Huber Julia, Burandt Eike-Christian, Lebeau Annette, Marx Andreas Holger, Terracciano Luigi, Heilenkötter Uwe, Jänicke Fritz, Müller Volkmar, Paluchowski Peter, Geist Stefan, Wilke Christian, Simon Ronald, Sauter Guido, Quaas Alexander
Abstract excerpt
Angiogenesis is a key process in tumor growth and progression, which is controlled by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs). In order to better understand the prevalence and prognostic value of VEGFR1 expression in breast cancer, a tissue microarray containing >2,100 breast cancer specimens, with clinical follow‑up data, was analyzed by immunohistochemistry using an antibody...
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