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Article

Mendelian Randomisation study of the influence of eGFR on coronary heart disease.

Scientific reports - 24 Jun 2016

Charoen Pimphen, Nitsch Dorothea, Engmann Jorgen, Shah Tina, White Jonathan, Zabaneh Delilah, Jefferis Barbara, Wannamethee Goya, Whincup Peter, Mulick Cassidy Amy, Gaunt Tom, Day Ian, McLachlan Stela, Price Jacqueline, Kumari Meena, Kivimaki Mika, Brunner Eric, Langenberg Claudia, Ben-Shlomo Yoav, Hingorani Aroon, Whittaker John, Pablo Casas Juan, Dudbridge Frank

Abstract excerpt

Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this association is causal or the result of confounding or reverse causation. In this study we applied Mendelian randomisation analysis using 17 genetic variants previously associated with eGFR to...

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Identifiers

PMID: 27338949
DOI: 10.1038/srep28514
PMCID: PMC4919785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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