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Article

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus

23 Jun 2016

Abstract excerpt

Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified emetine as HCMV inhibitor. Additional studies confirmed its anti-HCMV activities in human foreskin fibroblasts: EC50-40±1.72 nM, CC50-8±0.56 μM, and selectivity index of...

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PMID: 27336364
DOI: 10.1371/journal.ppat.1005717

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