Article
Motor neuropathy contributes to crouching in patients with Dravet syndrome.
Neurology - 19 Jul 2016
Gitiaux Cyril, Chemaly Nicole, Quijano-Roy Susana, Barnerias Christine, Desguerre Isabelle, Hully Marie, Chiron Catherine, Dulac Olivier, Nabbout Rima
Abstract excerpt
OBJECTIVE: Since SCN1A is expressed in the motor neuron initial segment, we explored whether motor neuron dysfunction could contribute to gait disturbance and orthopedic misalignment in patients with Dravet syndrome due to SCN1A mutations. METHODS: We assessed 12 consecutive patients who presented to our institution between January and March 2013. All of them were older than 2 years and were positive for the...
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