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Article

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome.

Pflugers Archiv : European journal of physiology - 1 Aug 2016

Balajthy András, Somodi Sándor, Pethő Zoltán, Péter Mária, Varga Zoltán, Szabó Gabriella P, Paragh György, Vígh László, Panyi György, Hajdu Péter

Abstract excerpt

In vitro manipulation of membrane sterol level affects the regulation of ion channels and consequently certain cellular functions; however, a comprehensive study that confirms the pathophysiological significance of these results is missing. The malfunction of 7-dehydrocholesterol (7DHC) reductase in Smith-Lemli-Opitz syndrome (SLOS) leads to the elevation of the 7-dehydrocholesterol level in the plasma membrane....

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PMID: 27315086
DOI: 10.1007/s00424-016-1851-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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