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Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin‐6 signaling in hepatocellular carcinoma

17 Jun 2016

Abstract excerpt

UNLABELLED: Several chronic inflammatory liver diseases, e.g., chronic hepatitis B or C viral infection and steatohepatitis, have been shown to predispose to the development of hepatocellular carcinoma (HCC). In patients with chronic liver disease, interleukin-6 (IL-6) serum levels are elevated and increase even more when HCC develops. However, the impact and regulatory mechanisms of IL-6 signaling during...

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PMID: 27311882
DOI: 10.1002/hep.28684

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