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Article

Ethnic specific association of the CAV1/CAV2 locus with primary open-angle glaucoma.

Scientific reports - 14 Jun 2016

Rong Shi Song, Chen Li Jia, Leung Christopher K S, Matsushita Kenji, Jia Liyun, Miki Atsuya, Chiang Sylvia W Y, Tam Pancy O S, Hashida Noriyasu, Young Alvin L, Tsujikawa Motokazu, Zhang Mingzhi, Wang Ningli, Nishida Kohji, Pang Chi Pui

Abstract excerpt

A single-nucleotide polymorphism (SNP) rs4236601 at the CAV1/CAV2 locus is associated with primary open-angle glaucoma (POAG). Rs4236601 is common in Caucasians but rare in East Asians. Here we conducted a haplotype-tagging SNP analysis followed by replication in a total of 848 POAG cases and 1574 controls drawn from 3 cities in China and 1 city in Japan. Two SNPs, rs4236601 (odds ratio [OR] = 6.25; P = 0.0086)...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27297022
DOI: 10.1038/srep27837
PMCID: PMC4906515

Genes

CAV1
CAV2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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