Article
Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles.
Cancer research - 1 Aug 2016
Jiang Xi, Bugno Jason, Hu Chao, Yang Yang, Herold Tobias, Qi Jun, Chen Ping, Gurbuxani Sandeep, Arnovitz Stephen, Strong Jennifer, Ferchen Kyle, Ulrich Bryan, Weng Hengyou, Wang Yungui, Huang Hao, Li Shenglai, Neilly Mary Beth, Larson Richard A, Le Beau Michelle M, Bohlander Stefan K, Jin Jie, Li Zejuan, Bradner James E, Hong Seungpyo, Chen Jianjun
Abstract excerpt
Acute myeloid leukemia (AML) is a common and fatal form of hematopoietic malignancy. Overexpression and/or mutations of FLT3 have been shown to occur in the majority of cases of AML. Our analysis of a large-scale AML patient cohort (N = 562) indicates that FLT3 is particularly highly expressed in some subtypes of AML, such as AML with t(11q23)/MLL-rearrangements or FLT3-ITD. Such AML subtypes are known to be...
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