Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants

3 Jun 2016

Abstract excerpt

Whole-genome sequencing data allow detection of copy number variation (CNV) at high resolution. However, estimation based on read coverage along the genome suffers from bias due to GC content and other factors. Here, we develop an algorithm called BIC-seq2 that combines normalization of the data at the nucleotide level and Bayesian information criterion-based segmentation to detect both somatic and germline CNVs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27260798
DOI: 10.1093/nar/gkw491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variantsPMID 27260798Read ↗

CNVPipe: An enhanced pipeline for accurate analysis of copy number variation from whole-genome sequencingSemantic proximity Read ↗

Robust somatic copy number estimation using coarse-to-fine segmentationSemantic proximity Read ↗

An integrative segmentation method for detecting germline copy number variations in SNP arrays.Semantic proximity Read ↗

ClinCNV: multi-sample germline CNV detection in NGS dataSemantic proximity Read ↗

Conumee 2.0: enhanced copy-number variation analysis from DNA methylation arrays for humans and miceSemantic proximity Read ↗

CNVannotator: a comprehensive annotation server for copy number variation in the human genome.Semantic proximity Read ↗

Computational tools for copy number variation (CNV) detection using next-generation sequencing data: features and perspectives.Semantic proximity Read ↗

High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications.Semantic proximity Read ↗

GATK-gCNV: A Rare Copy Number Variant Discovery Algorithm and Its Application to Exome Sequencing in the UK BiobankSemantic proximity Read ↗

CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing.Semantic proximity Read ↗

BMI-CNV: a Bayesian framework for multiple genotyping platforms detection of copy number variants.Semantic proximity Read ↗

Human copy number variants are enriched in regions of low mappability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.