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Article

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis

31 May 2016

Abstract excerpt

Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3-induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that abnormal activation or decreased expression of STAT3 promotes or inhibits the expression of...

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PMID: 27246830
DOI: 10.1158/0008-5472.can-15-3073

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