Article
C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies.
Neuro-degenerative diseases - 1 Jan 2016
Geiger Joshua T, Arthur Karissa C, Dawson Ted M, Rosenthal Liana S, Pantelyat Alexander, Albert Marilyn, Hillis Argye E, Crain Barbara, Pletnikova Olga, Troncoso Juan C, Scholz Sonja W
Abstract excerpt
BACKGROUND: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia affecting the elderly. The GGGGCC hexanucleotide expansion mutation at the C9orf72 locus has been identified as a major cause of amyotrophic lateral sclerosis and frontotemporal dementia, raising the question of whether this mutation is a factor in DLB. Furthermore, a small number of clinically diagnosed DLB patients...
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