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Article

Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia.

Scientific reports - 27 May 2016

Wali Gautam, Sutharsan Ratneswary, Fan Yongjun, Stewart Romal, Tello Velasquez Johana, Sue Carolyn M, Crane Denis I, Mackay-Sim Alan

Abstract excerpt

Hereditary spastic paraplegia (HSP) is an inherited neurological condition that leads to progressive spasticity and gait abnormalities. Adult-onset HSP is most commonly caused by mutations in SPAST, which encodes spastin a microtubule severing protein. In olfactory stem cell lines derived from patients carrying different SPAST mutations, we investigated microtubule-dependent peroxisome movement with time-lapse...

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Identifiers

PMID: 27229699
DOI: 10.1038/srep27004
PMCID: PMC4882512

Genes

SPAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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