Article
Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases.
PLoS neglected tropical diseases - 1 May 2016
Gaschignard Jean, Grant Audrey Virginia, Thuc Nguyen Van, Orlova Marianna, Cobat Aurélie, Huong Nguyen Thu, Ba Nguyen Ngoc, Thai Vu Hong, Abel Laurent, Schurr Erwin, Alcaïs Alexandre
Abstract excerpt
After sustained exposure to Mycobacterium leprae, only a subset of exposed individuals develops clinical leprosy. Moreover, leprosy patients show a wide spectrum of clinical manifestations that extend from the paucibacillary (PB) to the multibacillary (MB) form of the disease. This "polarization" of leprosy has long been a major focus of investigation for immunologists because of the different immune response in...
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