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A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome

23 May 2016

Abstract excerpt

BACKGROUND: Soluble protein and lipid mediators play essential roles in the tumor environment, but their cellular origins, targets, and clinical relevance are only partially known. We have addressed this question for the most abundant cell types in human ovarian carcinoma ascites, namely tumor cells and tumor-associated macrophages. RESULTS: Transcriptome-derived datasets were adjusted for errors caused by...

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PMID: 27215396
DOI: 10.1186/s13059-016-0956-6

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