Article
Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Aug 2016
Fang Fang, Peng Ting, Yang Shiming, Wang Weixi, Zhang Yinong, Li He
Abstract excerpt
Huntington's disease (HD) is an inherited neurodegenerative disease that is caused by the abnormal expansion of CAG repeats in the gene encoding huntingtin (Htt). Reduced AKT phosphorylation and inhibited AKT activity have been shown to be involved in mutant Htt (mHtt)-induced cell death. Lycium barbarum polysaccharide (LBP), the main bioactive component of Lycium barbarum, reportedly has neuroprotective roles in...
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